Dr. Tomáš Fiala
Research Interests
Development of chemical methods for editing protein post-translational modifications, with focus on chemokine receptors at the brain-immune interface. – supported by the Branco Weiss Fellowship
Investigation of bambusuril macrocycles as anion sensors and supramolecular catalysts. – supported by the SNSF Spark Grant
Development of chemical tools for targeted manipulation of CNS receptors. – supported by the ETH Career Seed Award
Curriculum Vitae
Publications
W.-L. Lee,+ X. Westergaard,+ C. Hwu,+ J. Hwu, T. Fiala, C. Lacefield, U. Boltaev, A. Mendieta, L. Lin, M. Sonders, K. Brown, K. He, W. Asher, J. Javitch, D. Sulzer,* D. Sames*
“Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain”
J. Am. Chem. Soc. 2024, 146, 9564–9574.
D. Kodr, T. Fiala*, H. Wennemers*
“The irreplaceable glycine: glycine homologs destabilize the collagen triple helix”
Tetrahedron Lett. 2024, 138, 154964.
K. Nomura, T. Fiala* and H. Wennemers*
“Carbohydrate Co-Solutes Stabilize Collagen Triple Helices”
ChemBioChem 2024, 25, e202300860.
Highlighted in external pageChemistryViews
V. Islami, P. Bittner, T. Fiala, N. B. Hentzen, R. Zenobi, H. Wennemers*
“Self-Sorting Collagen Heterotrimers”
J. Am. Chem. Soc. 2024, 146, 1789–1793.
Highlighted by the external pageAmerican Peptide Society
T. Fiala, R. Heeb, L. Vigliotti, and H. Wennemers*
“The Yin and Yang of How N-terminal Acyl Caps Affect Collagen Triple Helices”
Biomacromolecules, 2023, 24, 3954–3960.
Featured on the Front Cover of the external page9/2023 issue.
T. Fiala,+ E. P. Barros,+ R. Heeb, S. Riniker,* H. Wennemers*
“Predicting Collagen Triple Helix Stability Through Additive Effects of Terminal Residues and Caps”
Angew. Chem. Int. Ed., 2023, 62, e202214728.
Selected as Hot Paper. Highlighted in external pageChimia under Swiss Science Concentrates.
T. Fiala, E. P. Barros, M.-O. Ebert, E. Ruijsenaars, S. Riniker and H. Wennemers*
“Frame Shifts Affect the Stability of Collagen Triple Helices”
J. Am. Chem. Soc. 2022, 144, 18642-18649.
Highlighted in Spotlights on Recent JACS Publications.
T. Fiala, E. V. Mosharov, J. Wang, A. M. Mendieta, S. J. Choi, E. Fialova, C. Hwu, D. Sulzer* and D. Sames*
“Chemical Targeting of Rhodol Voltage-Sensitive Dyes to Dopaminergic Neurons”
ACS Chem. Neurosci. 2022, 13, 1251–1262.
Selected as ACS Editors’ Choice article.
S. Bhowmik,+ J. Galeta,+ V. Havel, M. Nelson, A. Faouzi, B. Bechand, M. Ansonoff, T. Fiala, A. Hunkele, A. C. Kruegel, J. E. Pintar, S. Majumdar, J. A. Javitch* and D. Sames*
“Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy”
Nat. Commun. 2021, 12, 3858.
T. Fiala,+ J. Wang,+ M. Dunn, P. Sebej, S. J. Choi, E. C. Nwadibia, E. Fialova, D. M. Martinez, C. E. Cheetham, K. J. Fogle, M. J. Palladino, Z. Freyberg, D. Sulzer* and D. Sames*
"Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain"
J. Am. Chem. Soc. 2020, 142, 9285–9301.
T. Fiala,+ K. Sleziakova,+ K. Marsalek, K. Salvadori and V. Sindelar*
"Thermodynamics of Halide Binding to a Neutral Bambusuril in Water and Organic Solvents"
J. Org. Chem. 2018, 83, 1903–1912.
T. Fiala,+ L. Ludvikova,+ D. Heger, J. Svec, T. Slanina, L. Vetrakova, M. Babiak, M. Necas, P. Kulhanek,* P. Klan* and V. Sindelar*
"Bambusuril as a One-Electron Donor for Photoinduced Electron Transfer to Methyl Viologen in Mixed Crystals"
J. Am. Chem. Soc. 2017, 139, 2597–2603.
T. Fiala and V. Sindelar*
"Supramolecular complexes of bambusuril with dialkyl phosphates"
Supramol. Chem. 2016, 28, 810-816.
T. Fiala and V. Sindelar*
"Synthesis of Norbornahemicucurbiturils"
Synlett 2013, 24, 2443-2445.
+ Contributed equally
* Corresponding author