Dr. Matthew Deen
Research Interests
The development of new tools to gain insight into the function and organization of biomacromolecules in their native cellular environments.
Curriculum Vitae
Publications
A.G. Santana, K. Robinson, C. Vickers, M.C. Deen, H. Chen, S. Zhou, B. Dai, M. Fuller, A.B. Boraston, D.J. Vocadlo, L.A. Clarke, S.G. Withers, Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher Animal Models. Angew. Chemie - Int. Ed., 2022
M.C. Deen,† Y. Zhu,† C. Gros, N. Na, P. Gilormini, D. Shen, S. Bhosale, R. Wang, F.C. Lynn, D.J. Vocadlo, A versatile substrate for quantitative measurement of glucocerebrosidase activity within live cells. Proc. Natl. Acad. Sci. U.S.A., 2022
S. Cecioni, R.A. Ashmus, P. Gilormini, S. Zhu, X. Chen, X, Shan, C. Gros, M.C. Deen, Y. Wang, Robert Britton, and David J. Vocadlo, Quantitative monitoring of glycosidase activity in live cells using sensitive fluorescence-quenched bis-acetal substrates. Nat. Chem. Biol., 18, 332–341 (2021)
M.C. Deen, C. Proceviat, X. Shan, L. Wu, D.L. Shen, G.J. Davies, D.J. Vocadlo., Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates. ACS Chem. Biol. 15, 824–829 (2020).
M. G. Alteen, C. Gros, R.W. Meek, D.A. Cardoso, J.A. Busmann, G. Sangouard, M.C. Deen, H.Y. Tan, D.L. Shen, C.C. Russell, G.J. Davies, P.J. Robinson, A. McCluskey, D.J. Vocadlo, A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase. Angew. Chemie - Int. Ed. 59, 9601–9609 (2020).
S.S.K. Abadi, M.C. Deen, J.N. Watson, F.S. Shidmoossavee, A.J. Bennet, Directed evolution of a remarkably efficient Kdnase from a bacterial neuraminidase. Glycobiology 30, 325–333 (2020).
Y. Zhu, X. Shan, F. Safarpour, N. Erro go, N. Li, A. Shan, M.C. Huang, M.C. Deen, V. Holicek, Z. Madden, S. Gorski, M.A. Silverman, D.J. Vocadlo, Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway. ACS Chem. Neurosci. 9, 1366–1379 (2018).
M.C. Deen, C. Shamshoom, A. Gamble, D. Bejan, N. J. Bunce, Electrodeposition of metal cations from the wet ionic liquid [EMIM][TFSI]. Can. J. Chem. 94, 170–175 (2015).
L.U. Ho, M.G. Shkoor, M.S. Hossain, M.C. Deen, D.V. Soldatov, A.L. Schwan, The base-mediated cyclization of selected benzyl alkynyl sulfones with aromatic aldehydes: Novel synthetic access to aryl-substituted 5,6-dihydro-1,4-oxathiin S,S -dioxides. J. Sulfur Chem. 34, 79–87 (2013).