Publications
Most recent publications
P. Hiebert, G. Antoniazzi, M. Aronoff, S. Werner, H. Wennemers
“A Lysyl Oxidase-Responsive Collagen Peptide Illuminates Collagen Remodeling in Wound Healing”
Matrix Biol. 2024, 128, 11-20. external pageAbstract
D. Kodr, T. Fiala, H. Wennemers
“The irreplaceable glycine: glycine homologs destabilize the collagen triple helix”
Tetrahedron Lett. 2024, 138, 154964. external pageAbstract
J. S. Möhler, M. Pickl, T. Reiter, S. Simić, J. W. Rackl, W. Kroutil, H. Wennemers
“Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions – Oxidation Followed by Conjugate Addition”
Angew. Chem. Int. Ed. 2024, 63, e202319457. external pageAbstract
Highlighted in external pageSynfacts
K. Nomura, T. Fiala, H. Wennemers
“Carbohydrate Co-Solutes Stabilize Collagen Triple Helices”
ChemBioChem 2024, 25, e202300860. external pageAbstract
Highlighted in external pageChemistryViews
T. Schnitzer, M. Schnurr, A. F. Zahrt, N. Sakhaee, S. E. Denmark, H. Wennemers
“Machine Learning to Develop Peptide Catalysts – Successes, Limitations and Opportunities”
ACS Cent. Sci. 2024, 10, 367–373. external pageAbstract
V. Islami, P. Bittner, T. Fiala, N. B. Hentzen, R. Zenobi, H. Wennemers
“Self-Sorting Collagen Heterotrimers”
J. Am. Chem. Soc. 2024, 146, 1789–1793. external pageAbstract.
Highlighted by the external pageAmerican Peptide Society
D. Hilvert, A. Pfaltz, H. Wennemers
Obituary of Albert Eschenmoser: “Albert Eschenmoser (1925–2023): A Giant of Organic Chemistry“
Angew. Chem. Int. Ed. 2023, 62, e202315565. external pageAbstract
S. Vela-Gallego, B. Lewandowski, J. Möhler, A. Puente, D. Gil-Cantero, H. Wennemers, A. de la Escosura
"Modifying the catalytic activity of lipopeptide assemblies with nucleobases"
Chem. Eur. J. 2023, 30, e202303395. external pageAbstract
M. Schnurr, J. W. Rackl, H. Wennemers
"Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ-Nitroaldehydes"
J. Am. Chem. Soc. 2023, 145, 23275–23280. external pageAbstract
Highlighted in external pageSynfacts
A. Markos, M. Biedermann, J. Heimgärtner, A. Schmitt, K. Lang, H. Wennemers
"Introducing Azomethine Imines to Chemical Biology: Bioorthogonal Reaction with Isonitriles"
J. Am. Chem. Soc. 2023, 145, 19513-19517. external pageAbstract
Highlighted in external pageSynfacts
B. Lewandowski, R. Schäfer, E. Cotter, D. Harangozo, H. Wennemers
"Catalytic templated length-controlled oligomerization"
Faraday Discuss. 2023, 244, 119-133. external pageAbstract
General discussion at the Faraday Discussion Meeting: external pageAbstract
G. Antoniazzi, R. Schäfer, M. Biedermann, E. Rüttimann, H. Wennemers
"Isonitrile-Proline – A Versatile Handle for the Chemoselective Derivatization of Collagen Peptides"
Chem. Eur. J. 2023, 29, e202302389. external pageAbstract
M. Him Chak, M. Schnurr, B. Lewandowski
“Aryl Crown Ethers Based on D-Glucose Scaffold – Highly Selective Receptors of Amino Acid Ester Hydrochlorides”
Eur. J. Org. Chem. 2023, 26, e202300305. external pageAbstract
T. Fiala, R. Heeb, L. Vigliotti, and H. Wennemers
“The Yin and Yang of How N-terminal Acyl Caps Affect Collagen Triple Helices”
Biomacromolecules, 2023, 24, 3954–3960. external pageAbstract DownloadPDF (PDF, 989 KB) Cover
A. Budinská, H. Wennemers
“Organocatalytic Synthesis of Triflones Bearing Two Non-adjacent Stereogenic Centers“
Angew. Chem. Int. Ed. 2023, 62, e202300537. external pageAbstract
Highlighted in external pageSynfacts and external pageChemistryViews
B. Lewandowski, D. Schmid, R. Borrmann, D. Zetschok, M. Schnurr, H. Wennemers
“Catalytic length-controlled oligomerization with synthetic programmable templates“
Nat. Synth. 2023, 2, 331–337. external pageAbstract
Highlighted in external pageNature Synthesis
T. Fiala, E. P. Barros, R. Heeb, S. Riniker and H. Wennemers
“Predicting Collagen Triple Helix Stability through Additive Effects of Terminal Residues and Caps”
Angew. Chem. Int. Ed. 2023, 62, e202214728. external pageAbstract
Highlighted in external pageChimia.
T. Schnitzer, N. Trapp and H. Wennemers
“Crystal structure analysis of N-acetylated proline and ring-size analogs“
J. Pept. Sci. 2023, 29, e3473. external pageAbstract
R. Schäfer, K. Wilson, M. Biedermann, B. Moore, S. Sieber, H. Wennemers
“Identification of Isonitrile-Containing Natural Products in Complex Biological Matrices Through Ligation with Chlorooximes“
Chem. Eur. J., 2023, 29, e202203277. external pageAbstract
R. Borrmann, D. Zetschok, H. Wennemers
“Decarboxylative Organocatalyzed Aldol-Type Addition Reaction of Chloroacetate Surrogates“
Org. Lett. 2022, 24, 47, 8683–8687. external pageAbstract
T. Fiala, E. P. Barros, M.-O. Ebert, E. Ruijsenaars, S. Riniker, H. Wennemers
“Frame Shifts Affect the Stability of Collagen Triple Helices“
J. Am. Chem. Soc. 2022, 144, 18642-18649. external pageAbstract DownloadPDF (PDF, 1012 KB)
Highlighted in external pageSpotlights on Recent JACS Publications
J. S. Möhler, L. K. Beiersdörfer, B. Masina, P. Wechsler, H. Wennemers
“Tripeptide Organocatalysts for Stereoselective Conjugate Addition Reactions with N-Heterocyclic Substituents“
Adv. Synth. Catal., 2022, 364, 3354-3359. external pageAbstract
T. Schnitzer, J. W. Rackl, H. Wennemers
“Stereoselective Peptide Catalysis in Complex Environments – From River Water to Cell Lysates“
Chem. Sci., 2022, 13, 8963–8967 external pageAbstract
Highlighted as external pageChemSci Pick of the Week and in external pageChemistryWorld
L. S. Mönkemöller, M. Schnurr, B. Lewandowski
“Chiral Recognition of Amino Acid Esters in Organic Solvents Using a Glucose-Based Receptor“
Molecules 2022, 27, 2177. external pageAbstract
G. Vastakaite, C. Grünenfelder, H. Wennemers
“Peptide-Catalyzed Stereoselective Conjugate Addition Reaction of Aldehydes to C-Substituted Maleimides“
Chem. Eur. J., 2022, 28, e202200215. external pageAbstract
Nina Romantini, Shahidul Alam, Stefanie Dobitz, Martin Spillmann, Martina De Foresta, Roger Schibli, Gebhard F. X. Schertler, Helma Wennemers, Xavier Deupi, Martin Behe, Philipp Berger
“Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone“
Proc. Natl. Acad. Sci. USA 2021, 118 (48) e2108776118 external pageAbstract
L. D. M. Nicholls, H. Wennemers
“Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides“
Chem. Eur. J. 2021, 27, 17559– 17564. external pageAbstract
M. R. Aronoff, P. Hiebert, N. B. Hentzen, S. Werner, H. Wennemers
“Imaging and targeting of LOX-mediated tissue remodeling with a reactive collagen peptide sensor“
Nat. Chem. Biol. 2021, 17, 865–871. external pageAbstract Cover
external pageHighlighted in C&E News, ETH News and in external pageBlick
H. Wennemers
“Peptides - Molecular Allrounders“
Chimia 2021, 75, 525-529. external pageAbstract
C. Thilgen, H. Wennemers, T. Carell
Orbituary of François Diederich: “François Diederich (1952–2020): 40 Years of Organic Chemistry“
Angew. Chem. Int. Ed. 2021, 60, 11562-11567. external pageAbstract
J. Egli, C. Esposito, M. Müri, S. Riniker, H. Wennemers
"Influence of Lipidation on the Folding and Stability of Collagen Triple Helices—An Experimental and Theoretical Study”
J. Am. Chem. Soc. 2021, 143, 5937–5942. external pageAbstract
P. Dominique, M. Schnurr, B. Lewandowski
"Chiral recognition of amino-acid esters by a glucose-derived macrocyclic receptor"
Chem. Commun. 2021, 57, 3476–3479. external pageAbstract
B. A.G. Lamers, A. Herdlitschka, T. Schnitzer, M. F.J. Mabesoone, S.M.C. Schoenmakers, B.F.M. de Waal, A.R.A. Palmans, H. Wennemers*, E.W. Meijer*
“Oligodimethylsiloxane-Oligoproline Block Co-Oligomers: the Interplay between Aggregation and Phase Segregation in Bulk and Solution”
J. Am. Chem. Soc. 2021, 143, 4032–4042. external pageAbstract
D. Zetschok, L. Heieck, H. Wennemers,
"Decarboxylative Organocatalyzed Addition Reactions of Fluoroacetate Surrogates for the Synthesis of Fluorinated Oxindoles”
Org. Lett. 2021, 23, 5, 1753–1757. external pageAbstract
T. Schnitzer, E. Paenurk, N. Trapp, R. Gershoni-Poranne, H. Wennemers,
“Peptide-Metal Frameworks with Metal Strings Guided by Dispersion Interactions“
J. Am. Chem. Soc. 2021, 143, 644–648. external pageAbstract
S. Dobitz, P. Wilhelm, N. Romantini, M. De Foresta, C. Walther, A. Ritler, R. Schibli, P. Berger, X. Deupi, M. Béhé, H. Wennemers, "Distance-Dependent Cellular Uptake of Oligoproline-Based Homobivalent Ligands Targeting GPCRs—An Experimental and Computational Analysis"
Bioconjugate Chem. 2020, 31, 2431–2438 external pageAbstract
J. S. Möhler,* T. Schnitzer,* H. Wennemers, „Amine Catalysis with Substrates Bearing N‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction”
Chem. Eur. J. 2020, 26, 15623–15628. external pageAbstract
M. Li, R. Puschmann, A. Herdlitschka, D. Fiedler, H. Wennemers, "Delivery of myo‐inositol hexakisphosphate to the cell nucleus with a proline‐based cell penetrating peptide"
Angew. Chem. Int. Ed. 2020, 59, 15586 –15589. external pageAbstract
T. Schnitzer, H. Wennemers, "Deactivation of Secondary Amine Catalysts via Aldol Reaction – Amine Catalysis under Solvent-free Conditions“
J. Org. Chem. 2020, 85, 7633−7640 external pageAbstract Cover
T. Schnitzer, R. L. Ganzoni, H. Wennemers, "Impact of the β-turn hydrogen bond on the trans/cis ratio and the performance of the peptide catalyst H-DPro-Pro-Glu-NH2“
Tetrahedron 2020, 76, 131184. external pageAbstract
M. R. Aronoff, J. Egli, A. Schmitt, H. Wennemers, "Alkylation of g-Azaproline Creates Conformationally Adaptable Proline Derivatives for pH-Responsive Collagen Triple Helices”
Chem. Eur. J. 2020, 26, 5070–5074 external pageAbstract
N. B. Hentzen, V. Islami, M. Köhler, R. Zenobi, H. Wennemers, "A Lateral Salt Bridge for the Specific Assembly of an ABC-Type Collagen Heterotrimer"
J. Am. Chem. Soc., 2020, 142, 2208-2212. external pageAbstract
T. Schnitzer,* J. S. Möhler,* H. Wennemers, "Effect of the Enamine Pyramidalization Direction on the Reactivity of Secondary Amine Organocatalysts“
Chem. Sci., 2020, 11, 1943–1947. external pageAbstract
T. Schnitzer, A. Budinska, H. Wennemers, “Organocatalyzed Conjugate Addition Reactions of Aldehydes to Nitroolefins with Anti-Selectivity”
Nat. Catal. 2020, 3, 143–147. external pageAbstract external pageHighlight in Synfacts external pageHighlighted in Trendberichte 2021
J. Egli,* T. Schnitzer,* J. C. B. Dietschreit, C. Ochsenfeld, H. Wennemers "Why Proline? Influence of Ring Size on the Collagen Triple Helix”
Org. Lett. 2020, 22, 348-351. external pageAbstract Coverart
R. J. B. Schäfer, M. R. Monaco, M. Li, A. Tirla, P. Rivera-Fuentes, H. Wennemers "The Bioorthogonal Isonitrile–Chlorooxime Ligation"
J. Am. Chem. Soc. 2019, 141, 18644–18648 external pageAbstract
external pageHighlight in Nature Chemical Biology external pageHighlight in F1000 prime
M. Köhler, A. Marchand, N. B. Hentzen, J. Egli, A. I. Begley, H. Wennemers, R. Zenobi "Temperature-controlled electrospray ionization mass spectrometry as a tool to study collagen homo- and heterotrimers"
Chem. Sci. 2019, 10, 9829–9835 external pageAbstract
A. Herdlitschka, B. Lewandowski, H. Wennemers "Organic Molecular Weaves"
Chimia 2019, 73, 450 - 454 external pageAbstract
N. A. K. Ochs,* U. Lewandowska,* W. Zajaczkowski, S. Corra, S. Reger, A. Herdlitschka, S. Schmid, W. Pisula, K. Müllen, P. Bäuerle, H. Wennemers "Oligoprolines guide the self-assembly of quaterthiophenes"
Chem. Sci., 2019, 10, 5391 - 5396 external pageAbstract
J. Egli, C. Siebler, M. Köhler, R. Zenobi, H. Wennemers
"Hydrophobic Moieties Bestow Fast-Folding and Hyperstability on Collagen Triple Helices",
J. Am. Chem. Soc., 2019, 141, 5607–5611 external pageAbstract
R. J. B. Schäfer, M. R. Aronoff, H. Wennemers "Recent Advances in Bioorthogonal Reactions"
Chimia 2019, 73, 308 - 312 external pageAbstract
T. Schnitzer, H. Wennemers "Effect of β3-Amino Acids on the Performance of the Peptidic Catalyst H-dPro-Pro-Glu-NH2"
Helv. Chim. Acta 2019, 102, e1900070. external pageAbstract
C. Foletti, N. Trapp, S. Loosli, B. Lewandowski, H. Wennemers “4-Naphthylmethyl Proline Forms a Channel Structure”
Helv. Chim. Acta 2019, 102, e1900052. external pageAbstract
S. Loosli,* C. Foletti,* M. Papmeyer, H. Wennemers “Synthesis of
4-(Arylmethyl)proline Derivatives”
Synlett 2019, 30, 508–510. external pageAbstract external pageHighlight in Synform
E. Cosimi, N. Trapp, M.-O. Ebert, H. Wennemers "Combined Experimental and Theoretical Study of Long-Range H-F Interactions in α-Fluoro Amides”
Chem. Commun. 2019, 55, 2253–2256. external pageAbstract
M. R. Aronoff,* J. Egli,* M. Menichelli, H. Wennemers "γ-Azaproline Confers pH-Responsiveness and Functionalizability on Collagen Triple Helices”
Angew. Chem. Int. Ed. 2019, 58, 3143–3146. external pageAbstract
A. Ritler, M. S. Shoshan, X. Deupi, P. Wilhelm, R. Schibli, H. Wennemers, M. Béhé "Elucidating the Structure−Activity Relationship of the Pentaglutamic Acid Sequence of Minigastrin with Cholecystokinin Receptor Subtype 2" Bioconjugate Chem. 2019, 30, 657−666. external pageAbstract
M. S. Shoshan, T. Vonderach, B. Hattendorf, H. Wennemers "Peptide‐coated Platinum Nanoparticles with Selective Toxicity against Liver Cancer Cells”
Angew. Chem. Int. Ed. 2019, 58, 4901-4905. external pageAbstract Highlight at ETH external pageHighlight at AerzteZeitung
C. Rigling, J. K. Kisunzu, J. Duschmalé, D. Häussinger, M. Wiesner, M. O. Ebert, H. Wennemers "Conformational Properties of a Peptidic Catalyst: Insights from NMR Spectroscopic Studies"
J. Am. Chem. Soc., 2018, 140, 10829-10838 external pageAbstract
T. Schnitzer, H. Wennemers "Effect of γ-Substituted Proline Derivatives on the Performance of the Peptidic Catalyst H-DPro-Pro-Glu-NH2"
Synthesis 2018, 22, 4377-4382. external pageAbstract
U. Lewandowska,* S. Corra,* W. Zajaczkowski,* N. A. K. Ochs,* M. S. Shoshan, J. Tanabe, S. Stappert, C. Li, E. Yashima, W. Pisula, K. Müllen, and H. Wennemers "Positional Isomers of Chromophore-Peptide Conjugates Self-Assemble Into Different Morphologies"
Chem. Eur. J. 2018, 24, 12623-12629. external pageAbstract
C. Foletti, R. A. Kramer, H. Mauser, U. Jenal, K. H. Bleicher, H. Wennemers "Functionalized Proline-Rich Peptides Bind the Bacterial Second Messenger c-di-GMP”
Angew. Chem, Int. Ed. 2018, 57, 7729-7733. external pageAbstract external pageHighlight in ChemViews
T. Schnitzer, H. Wennemers "Influence of the trans/cis Conformer Ratio on the Stereoselectivity of Peptidic Catalysts”
J. Am. Chem. Soc., 2017, 139, 15356-15362. external pageAbstract
J. Egli, R. S. Erdmann, P. J. Schmidt, H. Wennemers, „Effect of N- and C-terminal functional groups on the stability of collagen triple helices”
Chem. Commun. 2017, 53, 11036-11039. external pageAbstract
O. D. Engl, J. Saadi, E. Cosimi, H. Wennemers "Synthesis of Monothiomalonates (MTMs) – Versatile Thioester Enolate Equivalents for C–C Bond Formations”
Helv. Chim. Acta, 2017, 100, e1700196. external pageAbstract
N. B. Hentzen, L. E. J. Smeenk, J. Witek, S. Riniker, H. Wennemers "Cross-Linked Collagen Triple Helices by Oxime Ligation”
J. Am. Chem. Soc., 2017, 139, 12815–12820. external pageAbstract
S. Dobitz, M. R. Aronoff, H. Wennemers, "Oligoprolines as Molecular Entities for Controlling Distance in Biological and Material Sciences”
Acc. Chem. Res., 2017, 50, 2420–2428. external pageAbstract
S. Corra, M. S. Shoshan, H. Wennemers, "Peptide mediated formation of noble metal nanoparticles – Controlling size and spatial arrangement"
Curr. Opin., Chem. Biol., 2017, 40, 138–144 external pageAbstract
U. Lewandowska, W. Zajaczkowski,* S. Corra,* J. Tanabe, R. Borrmann, E. M. Benetti, S. Stappert, K. Watanabe, N. A. K. Ochs, R. Schaeublin, C. Li, E. Yashima, W. Pisula, K. Müllen, H. Wennemers "A Triaxial Supramolecular Weave"
Nat. Chem., 2017, 9, 1068–1072. external pageAbstract
Cover page, external pageHighlight in C&EN, ETH News and in external pageNature Chemistry
T. Schnitzer, M. Wiesner, P. Krattiger, J. D. Revell, H. Wennemers, "Is More Better? A Comparison of Tri- and Tetrapeptidic Catalysts”
Org. Biomol. Chem. 2017, 15, 5877 – 5881. external pageAbstract Cover page
J. Egli, C. Siebler, B. Maryasin, R.S. Erdmann, C. Bergande, C. Ochsenfeld, H. Wennemers, „pH-Responsive aminoproline-containing collagen triple helices”
Chem. Eur. J. 2017, 33, 7938–7944. external pageAbstract Cover page
T. Schnitzer, H. Wennemers, "Thieme Chemistry Journals Awardees – Where Are They Now? A Stereoselective Tripeptide Catalyst for Conjugate Addition Reactions of Acetophenones to Dicyanoolefins”
Synlett 2017, 28, 1282 – 1286. external pageAbstract
Y. A. Nagel,* P. S. Raschle,* H. Wennemers "Effect of Preorganized Charge Display on the Cell Penetrating Properties of Cationic Peptides”
Angew. Chem. Int. Ed. 2017, 56, 122 – 126. external pageAbstract
C. E. Grünenfelder,* J. K. Kisunzu,* N. Trapp, R. Kastl, H. Wennemers "Crystal Structures of Peptidic Catalysts of the H-DPro-Pro-Xaa Type"
Peptide Science 2017; 108:e22912. DOI: 10.1002/bip.22912. external pageAbstract
H. Wennemers, J. Kisunzu, B. Lewandowski, U. Lewandowska "(2S,4S)-(9H-Fluoren-9-ylmethoxycarbonyl)-4-azidoproline"
e-EROS Encyclopedia of Reagents for Organic Synthesis 2016, Published online, DOI: 10.1002/047084289X.rn01954. external pageAbstract
E. Cosimi, J. Saadi, H. Wennemers "Stereoselective Synthesis of α-Fluoro-γ-Nitrothioesters Under Organocatalytic Conditions”
Org. Lett. 2016, 18, 6014 – 6017. external pageAbstract
E. Cosimi,* O. D. Engl,* J. Saadi, M.-O. Ebert, H. Wennemers "Stereoselective Organocatalyzed Synthesis of α-Fluorinated β-Amino Thioesters and their Application in Peptide Synthesis”
Angew. Chem. Int. Ed. 2016, 55, 13127 – 13131. external pageAbstract
C. Grünenfelder, J. Kisunzu, H. Wennemers "Peptide-Catalyzed Stereoselective Conjugate Addition Reactions of Aldehydes to Maleimide"
Angew. Chem. Int. Ed. 2016, 55, 8571 – 8574. external pageAbstract
S. Corrà, U. Lewandowska, E. M. Benetti, H. Wennemers "Size-controlled formation of noble metal nanoparticles in aqueous solution with a thiol-free tripeptide"
Angew. Chem. Int. Ed. 2016, 55, 8542 – 8545. external pageAbstract Cover page
U. Lewandowska, W. Zajaczkowski, W. Pisula, Y. Ma, C. Li, K. Mullen, H. Wennemers "Effect of Structural Modifications on the Self-Assembly of Oligoprolines Conjugated with Sterically Demanding Chromophores"
Chem. Eur. J. 2016, 22, 3804 – 3809 external pageAbstract
J. Saadi, H. Wennemers "Enantioselective Aldol Reactions with Masked Fluoroacetates”
Nature Chem., 2016, 8, 276 – 280 external pageAbstract external pageHighlight in phys.org DownloadHiglight in Chimia (PDF, 155 KB) DownloadHighlight in Synfacts (PDF, 145 KB)
C. Siebler, B. Maryasin, M. Kuemin, R. S. Erdmann, C. Rigling, C. Grünenfelder, C. Ochsenfeld, H. Wennemers "Importance of Dipole Moments and Ambient Polarity for the Conformation of Xaa-Pro Moieties – A Combined Experimental and Theoretical Study”
Chem. Sci. 2015, 6, 6725 – 6730 external pageAbstract Coverpage
L. Garbuio, B. Lewandowski, P. Wilhelm, L. Ziegler, M. Yulikov, H. Wennemers, G. Jeschke, "Shape Persistence of PPII Helical Oligoprolines"
Chem. Eur. J. 2015, 21, 10747 – 10753 external pageAbstract
O. D. Engl, S. P. Fritz, H. Wennemers, "Stereoselective Organocatalytic Synthesis of Oxindoles with Adjacent Tetrasubstituted Stereocenters"
Angew. Chem. Int. Ed. 2015, 54, 8193 – 8197 external pageAbstract external pageHighlight in Synfacts
C. Siebler, N. Trapp, H. Wennemers, "Crystal Structure of (4S)-Aminoproline: Conformational Insight into a pH-Responsive Proline Derivative"
J. Pept. Sci. 2015, 21, 208 – 211 external pageAbstract
P. Wilhelm, B. Lewandowski, N. Trapp, H. Wennemers, "A Crystal Structure of an Oligoproline PPII-Helix, at Last"
J. Am. Chem. Soc. 2014, 136, 15829 – 15832 external pageAbstract external pageHighlight in C&E News
O. D. Engl, S. P. Fritz, A. Käslin, H. Wennemers, "An Organocatalytic Route to Dihydrocoumarins and Dihydroquinolinones in all Stereochemical Configurations"
Org. Lett. 2014, 16, 5454 – 5457 external pageAbstract
U. Lewandowska, W. Zajaczkowski, L. Chen, F. Bouillière, D. Wang, K. Koynov, W. Pisula, K. Müllen, H. Wennemers, "Hierarchical Supramolecular Assembly of Sterically Demanding π-Systems by Conjugation with Oligoprolines"
Angew. Chem. Int. Ed. 2014, 53, 12537 – 12541 external pageAbstract
B. Lewandowski, H. Wennemers, "Asymmetric Catalysis with Short-chain Peptides"
Curr. Opin. Chem. Biol. 2014, 22, 40 – 46 external pageAbstract
A. Kolarovic, A. Käslin, H. Wennemers, "Stereoselective Synthesis of Indolines via Organocatalytic Thioester Enolate Addition Reactions"
Org. Lett. 2014, 16, 4236 – 4239 external pageAbstract
C. Siebler, R. S. Erdmann, H. Wennemers, "Switchable Proline Derivatives: Tuning the Conformational Stability of the Collagen Triple Helix by pH Changes"
Angew. Chem. Int. Ed. 2014, 53, 10340 – 10344 external pageAbstract DownloadHighlight in Nature Chemistry (PDF, 951 KB)
Y. Arakawa, S. P. Fritz, H. Wennemers, "Organocatalytic Stereoselective Synthesis of Acyclic Nitrothioesters with All-Carbon Quaternary Stereogenic Centers"
J. Org. Chem. 2014, 79, 3937 – 3945 external pageAbstract
A. Bahlinger, S. P. Fritz, H. Wennemers "Stereoselective Metal-free Synthesis of β-Amino Thioesters Bearing Tertiary and Quaternary Stereogenic Centers"
Angew. Chem. Int. Ed. 2014, 53, 8779 – 8783 external pageAbstract DownloadHighlight in Synfacts (PDF, 138 KB)
J. Duschmalé, S. Kohrt, H. Wennemers "Peptide Catalysis in Aqueous Emulsions"
Chem. Commun. 2014, 50, 8109 – 8112 external pageAbstract Cover page
C. Siebler, R. S. Erdmann, H. Wennemers, "From Azidoproline to Functionalizable Collagen"
Chimia. 2013, 67, 891 – 895 external pageAbstract
C. Kroll, R. Mansi, F. Braun, S. Dobitz, H. Maecke, H. Wennemers, "Hybrid Bombesin Analogues – Combining an Agonist and an Antagonist in Defined Distances for Optimized Tumor Targeting"
J. Am. Chem. Soc. 2013, 135, 16793 – 16796 external pageAbstract external pageHighlight in "In the Pipeline"
F. Bächle, J. Duschmalé, C. Ebner, A. Pfaltz, H. Wennemers "Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Nitroolefins: Identification of Catalytic Intermediates and the Stereoselectivity-Determining Step by ESI-MS"
Angew. Chem. Int. Ed. 2013, 52, 12619 – 12623 external pageAbstract
E. Schillinger, M. Kü̈min, A. Digennaro, E. Mena-Osteritz, S.Schmid, H. Wennemers, P. Bauerle "Guiding Suprastructure Chirality of an Oligothiophene by a Single Amino Acid"
Chem. Mater. 2013, 25, 4511 – 4521 external pageAbstract
A. Digennaro, H. Wennemers, G. Joshi, S. Schmid, E. Mena-Osteritz, P. Bäuerle "Chiral Suprastructures of Asymmetric Oligothiophene-Hybrids Induced by a Single Proline"
Chem. Comm. 2013, 49, 10929 – 10931 external pageAbstract
R. Kastl, H. Wennemers, "Peptide-Catalyzed Stereoselective Conjugate Addition Reactions Generating All-Carbon Quaternary Stereogenic Centers"
Angew. Chem. Int. Ed. 2013, 52, 7228 – 7232 external pageAbstract
R. Kastl, Y. Arakawa, J. Duschmale, M. Wiesner, H. Wennemers, "Peptide-catalyzed 1,4-Addition Reactions of Aldehydes to Nitroolefins"
Chimia 2013, 67, 279 – 282 external pageAbstract
D. Seebach, X. Sun, M.-O. Ebert, W. B. Schweizer, N. Purkayastha, A. K. Beck, J. Duschmalé, H. Wennemers, T. Mukaiyama, M. Benohoud, Y. Hayashi, M. Reiher, "Stoichiometric Reactions of Enamines Derived from Diphenylprolinol Silyl Ethers with Nitro Olefins and Lessons for the Corresponding Organocatalytic Conversions – a Survey"
Helv. Chim. Acta 2013, 96, 799 – 852 external pageAbstract
C. Held, H. Hübner, R. Kling, Y. A. Nagel, H. Wennemers, P. Gmeiner "Impact of the Proline Residue on Ligand Binding of Neurotensin Receptor 2 (NTS2)-Selective Peptide–Peptoid Hybrids"
ChemMedChem, 2013, 8, 772 – 778 external pageAbstract
R. S. Erdmann, H. Wennemers, "Conformational stability of triazolyl functionalized collagen triple helices"
Bioorg. Med. Chem., 2013, 21, 3565 – 3568 external pageAbstract
J. Duschmalé. J. Wiest, M. Wiesner, H. Wennemers, "Effects of internal and external carboxylic acids on the reaction pathway of organocatalytic 1,4-addition reactions between aldehydes and nitroolefins"
Chem. Sci., 2013, 4, 1312 – 1318 external pageAbstract
Y. Arakawa, H. Wennemers, "Enamine Catalysis in Flow with an Immobilized Peptidic Catalyst"
ChemSusChem, 2013, 6, 242 – 245 external pageAbstract Cover page
J. Duschmalé, Y. Arakawa, H. Wennemers, “Peptide Catalysis” in Science of Synthesis: Asymmetric Organocatalysis"
Vol. 2 (Ed: K. Maruoka), Georg Thieme Verlag, 2012, Chapter 2.3.7
R. A. Kramer, K. H. Bleicher, H. Wennemers “Design and Synthesis of Nucleoproline Amino Acids for the Straightforward Preparation of Chiral and Conformationally Constrained Nucleopeptides”
Helv. Chim. Acta 2012, 95, 2621 – 2634 external pageAbstract
R. S. Erdmann, H. Wennemers "Effect of Sterically Demanding Substituents on the Conformational Stability of the Collagen Triple Helix"
J. Am. Chem. Soc., 2012, 134, 17117 – 17124 external pageAbstract
L. Nagel, C. Budke, R. S. Erdmann, A. Dreyer, H. Wennemers, T. Koop, N. Sewald, "Influence of Sequential Modifications and Carbohydrate Variations in Synthetic AFGP Analogues on Conformation and Antifreeze Activity"
Chem. Eur. J., 2012, 18, 12783 – 12793 external pageAbstract
H. Wennemers "Peptides as asymmetric catalysts and templates for the controlled formation of Ag nanoparticles"
J. Pept. Sci. 2012, 18, 437 – 441 external pageAbstract
R. S. Erdmann, H. Wennemers "Conformational Stability of Collagen Triple Helices Functionalized in the Yaa Position by Click Chemistry"
Org. Biomol. Chem. 2012, 10, 1982 – 1986 external pageAbstract Cover page
J. Duschmalé, H. Wennemers "Adapting to Substrate Challanges: Peptides as Catalysts for Conjugate Addition Reactions of Aldehydes to α,β-Disubstituted Nitroolefins"
Chem. Eur. J. 2012, 18, 1111 – 1120 external pageAbstract
P. Clerici, H. Wennemers "Mono Thiomalonates as Thioester Enolate Equivalents – Enantioselective 1,4-Addition Reactions to Nitroolefins under Mild Conditions"
Org. Biomol. Chem. 2012, 10, 110 – 113 external pageAbstract
G. Upert, F. Bouillère, H. Wennemers "Correlating Molecular with Nanoscopic Dimensions - Oligoprolines as Scaffolds for the Formation of Ag-Nanoparticles in Defined Sizes"
Angew. Chem. Int. Ed. 2012, 51, 4231 – 4234 external pageAbstract Coverpage
H. Wennemers "Asymmetric Catalysis with Peptides"
Chem. Commun. 2011, 47, 12036 – 12041 external pageAbstract
R. S. Erdmann, H. Wennemers "Importance of Ring Puckering versus Interstrand Hydrogen Bonds for the Conformational Stability of Collagen"
Angew. Chem. Int. Ed. 2011, 50, 6835 – 6838 external pageAbstract
Y. Arakawa, M. Wiesner, H. Wennemers "Efficient Recovery and Reuse of an Immobilized Peptidic Organocatalyst"
Adv. Synth. Catal. 2011, 353, 1201 – 1206 external pageAbstract DownloadHighlight in Synfacts (PDF, 86 KB)
Y. Nagel, M. Kuemin, H. Wennemers "Functionalizable Oligoprolines as Molecular Scaffolds"
Chimia 2011, 65, 264 – 267 external pageAbstract
M. Messerer, H. Wennemers "Reversing the Enantioselectivity of a Peptidic Catalyst by Changing the Solvent"
Synlett 2011, 4, 499 – 502 external pageAbstract
R. S. Erdmann, H. Wennemers, "Functionalizable Collagen Model Peptides"
J. Am. Chem. Soc. 2010, 132, 13957 – 13959 external pageAbstract
M. Kuemin, Y. A. Nagel, S. Schweizer, F. W. Monnard, C. Ochsenfeld, H. Wennemers, "Tuning the cis:trans Conformer Ratio of Xaa-Pro Amide Bonds by Intramolecular Hydrogen Bonds - Effect on the Stability of the PPII Helix"
Angew. Chem. Int. Ed. 2010, 49, 6324 – 6327 external pageAbstract
M. Kuemin, J. Engel, H. Wennemers, "Temperature Induced Transition between Polyproline I and II Helices – Quantitative Fitting of Hysteresis Effects"
J. Pept. Sci. 2010, 16, 596 – 600 external pageAbstract
G. Upert, C. A. Merten, H. Wennemers "Nanoliter Plates - Versatile Tools for the Screening of Split-and-Mix Libraries On-bead and Off-bead"
Chem. Commun. 2010, 46, 2209 – 2211 external pageAbstract
M. Wiesner, H. Wennemers, “Peptide Catalyzed Conjugate Addition Reactions of Aldehydes to Nitroolefins”
Synthesis 2010, 9, 1568 – 1571 external pageAbstract
P. Krattiger, N. Nassif, A. Völkel, Y. Mastai, H. Wennemers, H. Cölfen "Investigation of active crystal morphogenesis peptide sequences from peptide libraries by crystallization on peptide functionalized beads"
Colloids and Surfaces A: Physicochemical and Engineering Aspects 2010, 354, 218 – 225 external pageAbstract
M. Wiesner, G. Upert, G. Angelici, H. Wennemers "Enamine Catalysis with Low Catalyst Loadings – High Efficiency via Kinetic Studies"
J. Am. Chem. Soc. 2010, 132, 6 – 7 external pageAbstract Cover page
M. Kuemin, S. Schweizer, C. Ochsenfeld, H. Wennemers "Effects of Terminal Functional Groups on the Stability of the Polyproline II Structure – A Combined Experimental and Theoretical Study"
J. Am. Chem. Soc. 2009, 131, 15474 – 15482 external pageAbstract
M. Wiesner, M. Neuburger, H. Wennemers "Tripeptides of the Type H-D-Pro-Pro-Xaa-NH2 as Catalysts for Asymmetric 1,4-Addition Reactions: Structural Requirements for High Catalytic Efficiency"
Chem. Eur. J. 2009, 15, 10103 – 10109 external pageAbstract DownloadHighlight in Synform (PDF, 359 KB)
K. Belser, T. V. Slenters, C. Pfumbidzai, G. Upert, L. Mirolo, K. M. Fromm, H. Wennemers " Silver Nanoparticle Formation in Different Sizes Induced by Peptides Identified within Split-and-Mix Libraries"
Angew. Chem. Int. Ed., 2009, 48, 3661 – 3664 external pageAbstract
R. S. Erdmann, M. Kümin, H. Wennemers "(4R)- and (4S)-Azidoprolines – Conformation Directing Amino Acids and Sites for Functionalization"
Chimia 2009, 63, 197 – 200 external pageAbstract
R. S. Erdmann, H. Wennemers "Synthesis of Fmoc-Pro-Hyp(TBDPS)-Gly-OH and its Application as a Versatile Building Block for the Preparation of Collagen Model Peptides"
Synthesis 2009, 1, 143 – 147 external pageAbstract
M. Wiesner, J. D. Revell, S. Tonazzi, H. Wennemers "Peptide Catalyzed Asymmetric Conjugate Addition Reactions of Aldehydes to Nitroethylene – A Convenient Entry into γ2-Amino Acids"
J. Am. Chem. Soc. 2008, 130, 5610 – 5611 external pageAbstract external pageHighlight in C&E News DownloadHighlight in Synfacts (PDF, 79 KB)
J. D. Revell, H. Wennemers "Investigating Sequence Space: How Important is the Spatial Arrangement of Functional Groups in the Asymmetric Aldol Reaction Catalyst H-Pro-Pro-Asp-NH2?"
Adv. Synth. Catal. 2008, 350, 1046 – 1054 external pageAbstract
C. F. J. Faul, P. Krattiger, B. Smarsly, H. Wennemers "Ionic Self-Assembled Molecular Receptor-Based Liquid Crystals with Tripeptide Recognition Capabilities"
J. Mater. Chem. 2008, 18, 2962 – 2967 external pageAbstract DownloadHighlight in Synfacts (PDF, 107 KB)
M. Wiesner, J. D. Revell, H. Wennemers “Tripeptides as Efficient Asymmetric Catalysts for 1,4-Addition Reactions of Aldehydes to Nitroolefins - A Rational Approach”
Angew. Chem. Int. Ed. 2008, 47, 1871 – 1874 external pageAbstract
X. Y. Gong, D. Dobrunz, M. Kümin, M. Wiesner, J. D. Revell, H. Wennemers, P. Hauser, "Separating stereoisomers of di-, tri-, and tetrapeptides using capillary electrophoresis with contactless conductivity detection"
J. Sep. Sci. 2008, 31, 565 – 573 external pageAbstract
J. Bernard, H. Wennemers, "Macrocyclic Diketopiperazine Receptors – Effect of Macrocyclization on the Binding Properties of Two-armed Receptors"
Org. Lett. 2007, 9, 4283 – 4286 external pageAbstract
C. Aprile, F. Giacalone, M. Gruttadauria, A. Mossuto Marculescu, R. Noto, J. D. Revell, H. Wennemers "New ionic liquid-modified silica gels as recyclable materials for L-proline- or H-Pro-Pro-Asp-NH2-catalyzed aldol reactions”
Green Chemistry 2007, 9, 1328 – 1334 external pageAbstract
J. Lubkoll, H. Wennemers "Mimicry of Polyketide Synthases - Enantioselective 1,4-Addition Reactions of Malonic Acid Half Thioesters to Nitroolefins"
Angew. Chem. Int. Ed. Engl. 2007, 46, 6841 – 6844 external pageAbstract DownloadHighlight in Synfacts (PDF, 105 KB)
J. D. Revell, H. Wennemers "Functional Group Requirements for Catalysis of Aldol Reactions with the Peptide H-Pro-Pro-Asp-NH2"
Tetrahedron 2007, 63, 8420 – 8424 external pageAbstract
H. Wennemers "Peptides as Asymmetric Catalysts for Aldol Reactions"
Chimia 2007, 61, 276 – 278 external pageAbstract
J. D. Revell, H. Wennemers "Peptidic Catalysts Developed by Combinatorial Screening Methods"
Curr. Opin. Chem. Biol. 2007, 11, 269 – 278 external pageAbstract
J. D. Revell, H. Wennemers "Identification of Catalysts in Combinatorial Libraries"
Top. Curr. Chem. 2007, 277, 251 – 266 external pageAbstract
M. Kümin, L.-S. Sonntag, H. Wennemers "Azidoproline Containing Helices – Stabilization of the Polyproline II Structure by a Functionalizable Group"
J. Am. Chem. Soc. 2007, 129, 466 – 467 external pageAbstract
A. R. Stettler, P. Krattiger, H. Wennemers, M. Schwarz “Electrophoretic Affinity Measurements on Microchip – Determination of Binding Affinities between Diketopiperazine Receptors and Peptide Ligands”
Electrophoresis 2007, 28, 1832 – 1838 external pageAbstract
L.-S. Sonntag, S. Schweizer, C. Ochsenfeld, H. Wennemers “The “Azido Gauche Effect“ – Implications for the Conformation of Azidoprolines“
J. Am. Chem. Soc. 2006, 128, 14697 – 14703 external pageAbstract
J. Grun, J. D. Revell, M. Conza, H. Wennemers, “Peptide–Polyethylene Glycol Conjugates: Synthesis and Properties of Peptides Bearing a C-terminal Polyethylene Glycol Chain“
Bioorg. Med. Chem. 2006, 14, 6197 – 6201 external pageAbstract
J. D. Revell, D. Gantenbein, P. Krattiger, H. Wennemers, “Solid-supported and Pegylated H-Pro-Pro-Asp-NHR as Catalysts for Asymmetric Aldol Reactions“
Biopolymers (Pept. Sci.) 2006, 84, 105 – 113 external pageAbstract
P. Krattiger, R. Kovasy, J. D. Revell, H. Wennemers "Using Catalyst-Substrate Coimmobilization for the Discovery of Catalysts for Asymmetric Aldol Reactions in Split-and-Mix Libraries"
QSAR Comb. Sci. 2005, 24, 1158 – 1163 external pageAbstract
M. Nold, K. Koch, H. Wennemers "Acid-Rich Peptides are Prone to Damage under Fenton Conditions - Split-and-Mix Libraries for the Detection of Selective Peptide Cleavage"
Synthesis 2005, 9, 1455 – 1458 external pageAbstract
P. Krattiger, R. Kovasy, J. D. Revell, S. Ivan, H. Wennemers "Increased Structural Complexity Leads to Higher Activity: Peptides as Efficient and Versatile Catalysts for Asymmetric Aldol Reactions"
Org. Lett. 2005, 7, 1101 – 1103 external pageAbstract
P. Krattiger, H. Wennemers "Water-soluble Diketopiperazine Receptors: Selective Recognition of Arginine-Rich Peptides"
Synlett 2005, 4, 706 – 708 external pageAbstract
J.W. Lörgen, P. Krattiger, C. Kreuz, H. Wennemers, J. Bargon, "Diketopiperazine Receptors: Highly Selective Layers for Gravimetric Sensors"
Sensors and Actuators B: Chemical 2005, 107, 366 – 371 external pageAbstract
M. Nold, H. Wennemers "Peptide Damage under Fenton Conditions is Sequence Dependent"
Chem. Commun. 2004, 16, 1800 – 1801 external pageAbstract
L.-S. Sonntag, S. Ivan, M. Langer, M.M. Conza, H. Wennemers, "Functionalised Cyclotriproline - A Bowl-shaped Tripodal Scaffold"
Synlett 2004, 7, 1270 – 1272 external pageAbstract
H. Wennemers, "Combinatorial Methods for the Discovery of Catalysts", in "Highlights in Bioorganic Chemistry",
Wiley-VCH Weinheim 2004, edited by C. Schmuck and H. Wennemers, 436 – 445 external pageAbstract
H. Wennemers, "Peptide Receptors - From Selective Molecular Recognition towards Catalytic Activity"
Chimia 2003, 57, 237 – 240 external pageAbstract
P. Krattiger, C. McCarthy, A. Pfaltz, H. Wennemers “Catalyst-Substrate Coimmobilization: A Strategy for Catalyst Discovery in Split-and-Mix Libraries”
Angew. Chem. Int. Ed. 2003, 42, 1722-1724 external pageAbstract
H. Wennemers, M. Conza, “Determination of Binding Affinities on Solid Supports: Influence of the Loading and the Nature of the Solid Support”
Chem. Commun. 2003, 7, 866 – 867 external pageAbstract
H. Wennemers, M. Nold, M. Conza, K. J. Kulicke, M. Neuburger “Flexible but with a Defined Turn - Influence of the Template on the Binding Properties of Two-armed Receptors”
Chem Eur. J. 2003, 9, 442 – 448 external pageAbstract
M. Conza, H. Wennemers “Selective Binding of Diketopiperazine Receptors to Sidechain-protected Peptides"
J. Org. Chem. 2002, 67, 2696 – 2698 external pageAbstract
H. Wennemers, M. Conza, M. Nold, P. Krattiger “Diketopiperazine Receptors - A Novel Class of Highly Selective Receptors for Binding Small Peptides”
Chem. Eur. J. 2001, 7, 3342 – 3347 external pageAbstract
H. Wennemers, "Combinatorial Chemistry: A Tool for the Discovery of New Catalysts"
Comb. Chem. High Throughput Screening 2001, 4, 273 – 285 external pageAbstract
M. Conza, M. Nold, H. Wennemers "Sequence-selective Binding of Small Peptides by Two-armed Receptors"
ECSOC-4 2000, 1334 – 1337
H. Wennemers, “34th EUCHEM Conference on Stereochemistry, Bürgenstock, 1999”
Chimia 1999, 53, 403 – 407 (Conference Report)
H. Wennemers, “Towards the Development of Sequence-Selective Artificial Proteases”
Chimia 1999, 53, 229 – 230
G. Quinkert, S. Scherer, D. Reichert, H.P. Nestler, H. Wennemers, A. Ebel, K. Urbahns, K. Wagner, K.-P. Michaelis, G. Wiech, G. Prescher, B. Bronstert, B.-J. Freitag, I. Wicke, D. Lisch, P. Belik, T. Crecelius, D. Höchstermann, G. Zimmermann, J.W. Bats, G. Dürner, D. Rehm, “Stereoselective Ring Opening of Electronically Excited Cyclohexa-2,4-dienones: Cause and Effect”
Helv. Chim. Acta 1997, 80, 1683 – 1772
F. Gasparrini, D. Misiti, W.C. Still, C. Villani, H. Wennemers, “Enantioselective and Diastereoselective Binding Study of Silica Bound Macrobicyclic Receptors by HPLC”
J. Org. Chem. 1997, 62, 8221 – 8224 external pageAbstract
H.P. Nestler, H. Wennemers, R. Sherlock, D.L.Y. Dong, “Microautoradiographic Identification of Receptor-LigandInteractions in Bead-Supported Combinatorial Libraries”
Bioorg. Med. Chem. Lett. 1996, 6, 1327 – 1330
M. Maletic, H. Wennemers, D.Q. McDonald, R.C. Breslow, W.C. Still, "Selective Binding of the Dipeptides L-Phe-D-Pro and D-Phe-L-Pro to b-cyclodextrin"
Angew. Chem. Int. Ed. Engl. 1996, 35, 1490 – 1492
H. Wennemers, S.S. Yoon, W.C. Still, “Cyclooligomeric Receptors Based on Trimesic Acid and 1,2-Diamines. Minimal Structure for Sequence-Selective Peptide Binding”
J. Org. Chem. 1995, 60, 1108 – 1109
H. Wennemers, W.C. Still, “Peptide Complexation in Water. “Sequence Selective Binding with Simple Dye Molecules”
Tetrahedron Lett. 1994, 35, 6413 – 6416